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Plasma thyroxine changes of the Apollo Crewman.

M Sheinfeld, C S Leach, P C Johnson

    Aviation, Space, and Environmental Medicine
    |January 1, 1975
    PubMed
    Summary

    Apollo missions altered thyroid hormone levels in astronauts. Post-mission, astronauts showed increased thyroxine and free thyroxine index, with decreased cholesterol and triglycerides, suggesting mission activities impact thyroid function.

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    Area of Science:

    • Space medicine
    • Endocrinology
    • Human physiology

    Background:

    • Understanding the physiological effects of space missions on astronauts is crucial for long-duration spaceflight.
    • Thyroid hormones play a vital role in regulating metabolism and energy balance.

    Purpose of the Study:

    • To investigate the impact of Apollo mission activities on astronaut thyroid hormone levels.
    • To assess changes in serum lipids and proteins in relation to thyroid function post-mission.

    Main Methods:

    • Blood samples were collected from an Apollo crew member pre-mission, at recovery, and post-mission.
    • Analysis included measurements of thyroxine, free thyroxine index, T3 binding percentage, serum cholesterol, triglycerides, total serum proteins, and albumin.

    Main Results:

    • Statistically significant increases in thyroxine and free thyroxine index were observed at recovery.
    • Serum cholesterol and triglycerides showed a significant decrease post-mission.
    • No significant changes were found in T3 binding percentage, total serum proteins, or albumin.

    Conclusions:

    • Apollo mission activities and environment induced changes in thyroid hormone levels.
    • The observed post-mission increase in serum cholesterol may be linked to elevated thyroxine activity.
    Keywords:
    NASA Experiment Number AP008

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