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Stroke severity determines body temperature in acute stroke.

G Boysen¹, H Christensen

¹Department of Neurology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. gb01@bbh.hosp.dk

|February 7, 2001

Summary

In major stroke, a temperature rise hours after onset, not initial fever, correlated with poor outcome. Early elevated body temperature on admission did not predict stroke severity or 3-month outcomes.

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Area of Science:

Neurology
Clinical Medicine
Stroke Research

Background:

Previous studies suggested admission temperature predicts acute stroke prognosis.
Experimental data indicated hyperthermia might worsen infarct size.
This study investigated the prognostic value of initial body temperature in acute stroke patients.

Purpose of the Study:

To test the hypothesis that initial body temperature influences stroke outcome.
To determine if early temperature changes correlate with stroke severity.
To assess the prognostic significance of admission temperature within 6 hours of stroke onset.

Main Methods:

Prospective study of 725 acute stroke patients (cerebral infarcts and intracerebral hemorrhages).
Body temperature measured on admission and every 2 hours for 24 hours.

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Patients stratified by stroke severity using the Scandinavian Stroke Scale Score (SSS).

Main Results:

Mean admission temperature was normal; temperature rose 4-6 hours post-onset in major stroke.
Increased temperature 10-12 hours after onset correlated with poor outcome in major stroke.
Initial temperature >37.5°C was not linked to stroke severity or 3-month outcome.

Conclusions:

In major stroke, temperature rise occurs hours after onset, linked to infarcts/hemorrhages, not initial severity.
Elevated admission temperature within 6 hours did not predict 3-month stroke outcome.
Prognostic significance lies in temperature changes post-stroke, not initial readings.