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Related Experiment Videos

Probiotics--compensation for lactase insufficiency.

M de Vrese1, A Stegelmann, B Richter

  • 1Institute of Physiology and Biochemistry of Nutrition, Federal Dairy Research Center, Hermann-Weigmann-Strasse 1, D-24103 Kiel, Germany. devrese@bafm.de

The American Journal of Clinical Nutrition
|February 7, 2001
PubMed
Summary
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Yogurt and probiotic bacteria aid lactose digestion and reduce intolerance symptoms by providing microbial beta-galactosidase. Bacterial cell walls protect the enzyme, enhancing its effectiveness in the small intestine.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Nutritional Science

Background:

  • Lactose intolerance affects a significant portion of the global population.
  • Conventional starter cultures and probiotic bacteria in dairy products are known to influence lactose digestion.
  • Mechanisms behind these effects, including enzyme activity and gastrointestinal transit, require further elucidation.

Purpose of the Study:

  • To investigate the efficacy of yogurt and probiotic bacteria in improving lactose digestion and alleviating intolerance symptoms.
  • To explore the role of microbial beta-galactosidase and bacterial cell wall integrity in these beneficial effects.
  • To differentiate between lactose maldigestion and lactose intolerance and the impact of probiotics on each.

Main Methods:

  • Analysis of microbial beta-galactosidase activity in fermented and unfermented milk products.

Related Experiment Videos

  • Assessment of gastrointestinal transit time influenced by dairy product consumption.
  • Evaluation of clinical symptoms and hydrogen exhalation in lactose maldigesters consuming these products.
  • Comparison of the efficiency of yogurt cultures versus probiotic bacteria in lactose digestion.

    • Main Results:

    • Yogurt and starter cultures significantly improve lactose digestion and reduce intolerance symptoms in maldigesters.
    • Microbial beta-galactosidase, protected by intact bacterial cell walls, is key to enzyme efficacy.
    • Probiotic bacteria are generally less efficient at small intestine lactose digestion than yogurt cultures but may alleviate symptoms.
    • A poor correlation exists between lactose maldigestion markers (e.g., hydrogen exhalation) and clinical symptom improvement.

    Conclusions:

    • Fermented dairy products with live cultures are effective for managing lactose intolerance.
    • Bacterial integrity and enzyme delivery to the small intestine are critical for optimal lactose digestion.
    • Probiotics may offer symptomatic relief for lactose intolerance through mechanisms beyond direct lactose digestion.