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Related Experiment Videos

Probiotics and safety.

N Ishibashi1, S Yamazaki

  • 1Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd., Higashihara, Japan. n_ishibs@morinagamilk.co.jp

The American Journal of Clinical Nutrition
|February 7, 2001
PubMed
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Recent findings show probiotic bacteria, including lactic acid bacteria and bifidobacteria, isolated from infections, raising safety concerns. This review examines probiotic safety factors like pathogenicity and infectivity.

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Probiotics, primarily lactic acid bacteria and bifidobacteria, are widely used for health benefits.
  • Recent isolations of these bacteria from infection sites challenge their established safety profile.
  • This raises significant concerns regarding the safety of probiotic use.

Purpose of the Study:

  • To review the current status of probiotic bacteria isolation from infections.
  • To identify and discuss critical factors for assessing probiotic safety.
  • To present a model for evaluating probiotic safety using gnotobiotic mice.

Main Methods:

  • Review of literature on probiotic bacteria isolation from clinical infections.
  • Analysis of key safety assessment factors: pathogenicity, infectivity, and toxicity.

Related Experiment Videos

  • Description of monoassociation of gnotobiotic mice with Bifidobacterium longum to assess infection risk.
  • Evaluation of bacterial translocation and immune responses in the monoassociation model.

    • Main Results:

    • Probiotic bacteria, including common strains, are increasingly isolated from infection sources.
    • Comprehensive safety evaluation requires consideration of pathogenicity, infectivity, toxicity, and intrinsic bacterial properties.
    • Monoassociation models in gnotobiotic mice provide insights into infection potential and host response.

    Conclusions:

    • The safety of probiotics requires rigorous, multi-faceted assessment due to emerging reports of infections.
    • Factors such as pathogenicity, infectivity, and toxicity must be thoroughly evaluated for each probiotic strain.
    • Animal models like monoassociation in gnotobiotic mice are valuable tools for assessing probiotic safety and host interactions.