Searching for targets: the power of somatic cell genetics

Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis.

Cold Spring Harbor symposia on quantitative biology·2006

Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2001

Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence.

Journal of mammary gland biology and neoplasia·2001

DNA replication licensing and human cell proliferation.

Journal of cell science·2001

Stromal cells can contribute oncogenic signals.

Seminars in cancer biology·2001

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes.

Nature·2001

Robust annotation and discovery of novel cell types in single-cell ATAC-seq data through cross-modal reference alignment.

Genome research·2026

Identification of differential topologically associating domains from low sequencing depth and pseudo-bulk chromatin contact maps.

Genome research·2026

Quartet-based species tree methods enable fast and consistent tree of blobs reconstruction under the network multispecies coalescent.

Genome research·2026

Achieving spatial multiomics diagonal integration from unaligned serial sections with DIME.

Genome research·2026

A network of steroid receptor transcription factors regulates ovarian chromatin remodelling in the transition to ovulation.

Genome research·2026

Accurate reconstruction of spatial cell type maps and characterization of domain-specific functions based on a gene-aware heterogeneous network.

Genome research·2026

AGG repeat expansion and aggregation of BIN1 in multiple system atrophy.

Brain : a journal of neurology·2026

[Optical genome mapping analysis of a Chinese pedigree with a complex balanced translocation involving four chromosomes].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2026

[Pathogenicity analysis and prenatal genetic counseling for five Chinese pedigrees harboring a hemizygous c.-32C>G variant of FGF13 gene].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2026

Interim analysis of an international multi-site prospective natural history study evaluating the clinical presentation and progression of Leigh syndrome spectrum disorders.

Therapeutic advances in rare disease·2026

Systematic genotype-phenotype mapping and transcriptomic analyses highlight SEMA6A as a candidate for neuronal migration defects in 5q22-q23 deletions.

Journal of human genetics·2026

Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology.

Science (New York, N.Y.)·2026

Related Experiment Videos

Searching for targets: the power of somatic cell genetics

Related Concept Videos

Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis.

Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer.

Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence.

DNA replication licensing and human cell proliferation.

Stromal cells can contribute oncogenic signals.

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes.

Robust annotation and discovery of novel cell types in single-cell ATAC-seq data through cross-modal reference alignment.

Identification of differential topologically associating domains from low sequencing depth and pseudo-bulk chromatin contact maps.

Quartet-based species tree methods enable fast and consistent tree of blobs reconstruction under the network multispecies coalescent.

Achieving spatial multiomics diagonal integration from unaligned serial sections with DIME.

A network of steroid receptor transcription factors regulates ovarian chromatin remodelling in the transition to ovulation.

Accurate reconstruction of spatial cell type maps and characterization of domain-specific functions based on a gene-aware heterogeneous network.

AGG repeat expansion and aggregation of BIN1 in multiple system atrophy.

[Optical genome mapping analysis of a Chinese pedigree with a complex balanced translocation involving four chromosomes].

[Pathogenicity analysis and prenatal genetic counseling for five Chinese pedigrees harboring a hemizygous c.-32C>G variant of FGF13 gene].

Interim analysis of an international multi-site prospective natural history study evaluating the clinical presentation and progression of Leigh syndrome spectrum disorders.

Systematic genotype-phenotype mapping and transcriptomic analyses highlight SEMA6A as a candidate for neuronal migration defects in 5q22-q23 deletions.

Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology.

Related Experiment Videos

Searching for targets: the power of somatic cell genetics

Related Concept Videos

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