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Regional and global changes in cerebral diffusion with normal aging.

A O Nusbaum1, C Y Tang, M S Buchsbaum

  • 1Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA.

AJNR. American Journal of Neuroradiology
|February 13, 2001
PubMed
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Quantitative diffusion MRI reveals age-related white matter changes. Diffusion histograms can globally assess normal aging and aid comparison with neurodegenerative diseases.

Area of Science:

  • Neuroimaging
  • Radiology
  • Gerontology

Background:

  • Normal aging involves microstructural changes in white matter.
  • Conventional MRI may not detect subtle age-related alterations.

Purpose of the Study:

  • Investigate white matter microstructural changes during normal aging using quantitative diffusion MRI.
  • Identify regional anisotropy changes and quantify global changes with diffusion histograms.

Main Methods:

  • Diffusion tensor MRI performed on 20 healthy volunteers (20-91 years).
  • Calculated relative anisotropy (RA) and performed linear regression with age.
  • Analyzed average apparent diffusion coefficient (ADC) histograms for group comparisons.

Main Results:

Related Experiment Videos

  • Decreased RA observed in periventricular and frontal white matter, corpus callosum genu/splenium with age.
  • Increased RA found in internal capsules.
  • Older adults showed higher mean ADC and reduced histogram peak height/skew.

Conclusions:

  • Quantitative diffusion histograms correlate with normal aging.
  • Diffusion histograms offer a global assessment of age-related white matter changes.
  • Provides a standard for comparison with neurodegenerative conditions.