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[Acute meningococcal infection (author's transl)].

E G Pérez-Yarza, J Múgica, M Zabaleta

    Anales Espanoles De Pediatria
    |May 1, 1979
    PubMed
    Summary

    This study details 49 cases of acute meningococcal infection, finding all strains resistant to sulphamides. Mortality was 14% overall, highlighting the severity of this bacterial meningitis.

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    Area of Science:

    • Infectious Diseases
    • Bacteriology
    • Clinical Medicine

    Background:

    • Acute meningococcal infection poses a significant public health challenge.
    • Bacteriological diagnosis is crucial for effective treatment and understanding disease epidemiology.
    • Neisseria meningitidis strains exhibit varying group prevalences and antimicrobial resistance patterns.

    Purpose of the Study:

    • To report on the clinical and microbiological features of acute meningococcal infections.
    • To analyze the susceptibility of Neisseria meningitidis isolates to sulphamides.
    • To assess the outcomes and mortality associated with meningococcal disease.

    Main Methods:

    • Bacteriological diagnosis of 49 patients with acute meningococcal infection over 12 months.
    • Blood and cerebrospinal fluid (CSF) cultures for Neisseria meningitidis identification.
    • Serogroup determination (A, B, untyped) and sulphamide resistance testing.
    • Clinical data collection including symptoms, signs, and complications like endotoxic shock.

    Main Results:

    • Neisseria meningitidis was confirmed in 49 of 76 clinically diagnosed cases.
    • Prevalent serogroup was B (31 cases), followed by untyped (17) and A (1 case).
    • All isolates were resistant to sulphamides; endotoxic shock occurred in 26.5% with 53% mortality in this subgroup.

    Conclusions:

    • Acute meningococcal infections in this cohort were characterized by sulphamide-resistant strains, predominantly serogroup B.
    • Endotoxic shock significantly increases mortality in meningococcal disease.
    • Review of therapeutic strategies and chemoprophylaxis is essential for managing outbreaks.

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