Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated interstitial adenosine concentrations do not activate the muscle reflex.

D A MacLean1, L M Vickery, L I Sinoway

  • 1Division of Cardiology, Department of Medicine, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey Pennsylvania, 17033, USA. dmaclean@psu.edu

American Journal of Physiology. Heart and Circulatory Physiology
|February 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise.

Journal of human hypertension·2008
Same author

Muscle reflex control of sympathetic nerve activity in heart failure: the role of exercise conditioning.

Heart failure reviews·2005
Same author

Oxidative stress and nitric oxide synthase in skeletal muscles of rats with post-infarction, compensated chronic heart failure.

Acta physiologica Scandinavica·2005
Same author

Gender affects sympathetic neurovascular control during postural stress.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2004
Same author

The exercise metaboreflex is maintained in the absence of muscle acidosis: insights from muscle microdialysis in humans with McArdle's disease.

The Journal of physiology·2001
Same author

Gender affects sympathetic and hemodynamic response to postural stress.

American journal of physiology. Heart and circulatory physiology·2001
Same journal

Interplay of Oxidative Stress and Inflammatory Mechanisms in Doxorubicin-induced Cardiomyopathy.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

Impact of moderate isocapnic hyperthermia on dynamic cerebral autoregulation and its directional sensitivity.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

Repetitive Pressure Overload; Species Disparities, Mechanisms and Translational Relevance.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

SIRT2-mediated regulation of glycolytic flux: Another brick in the wall of Gary Lopaschuk's legacy in cardiac metabolism.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

Tailored anesthesia protocols for echo-based HFpEF phenotyping in C57BL6/N mice.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

Desmoglein-2 Deficiency Drives Mitochondrial Morphological Remodeling in Cardiomyocytes.

American journal of physiology. Heart and circulatory physiology·2026
See all related articles

Elevated interstitial adenosine concentrations in cat triceps surae muscle do not trigger cardiovascular responses or activate muscle reflexes, suggesting adenosine

Area of Science:

  • Cardiovascular Physiology
  • Exercise Physiology
  • Neuroscience

Background:

  • Adenosine plays a role in regulating blood flow and muscle function.
  • Previous studies suggest adenosine may influence muscle reflexes.
  • Understanding adenosine's role in muscle physiology is crucial for exercise science.

Purpose of the Study:

  • To investigate the impact of adenosine perfusion on interstitial adenosine levels in cat triceps surae muscle.
  • To determine the effects of elevated interstitial adenosine on heart rate and blood pressure.
  • To assess whether increased interstitial adenosine activates muscle reflexes.

Main Methods:

  • Isolated triceps surae muscle perfusion in decerebrate cats.
  • Microdialysis to measure interstitial adenosine concentrations.

Related Experiment Videos

  • Monitoring heart rate and blood pressure during adenosine perfusion.

    • Main Results:

    • Interstitial adenosine significantly increased with 20 mM and 100 microM adenosine perfusion.
    • No significant changes in heart rate or blood pressure were observed.
    • Muscle reflexes remained intact despite elevated interstitial adenosine.

    Conclusions:

    • Elevated interstitial adenosine does not activate the muscle reflex.
    • Adenosine's role in cardiovascular responses during exercise may be indirect.
    • Findings align with previous human studies on adenosine and muscle reflexes.