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InterPro--an integrated documentation resource for protein families, domains and functional sites
R Apweiler1, T K Attwood, A Bairoch
1EMBL Outstation--European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Bioinformatics (Oxford, England)
|February 13, 2001
Summary
InterPro integrates protein family, domain, and functional site data from multiple databases. This resource provides unified access to over 3000 entries, enhancing protein research.
Area of Science:
- Bioinformatics
- Proteomics
- Structural Biology
Background:
- InterPro is an integrated resource for protein families, domains, and functional sites.
- It rationalizes complementary efforts from PROSITE, PRINTS, Pfam, and ProDom databases.
Purpose of the Study:
- To create a unified documentation resource for protein data.
- To provide a single point of access for protein family and domain information.
Main Methods:
- Merging annotations from PRINTS, PROSITE, and Pfam into the InterPro core.
- Assigning unique accession numbers to merged and individual entries.
- Integrating regular expressions, profiles, fingerprints, and Hidden Markov Models (HMMs).
Main Results:
- InterPro Release 1.2 (June 2000) contains over 3000 entries.
- Entries represent protein families, domains, repeats, and post-translational modification (PTM) sites.
- Over 1 million matches against SWISS-PROT and TrEMBL were recorded.
Conclusions:
- InterPro offers a comprehensive and integrated view of protein domain and family information.
- The resource facilitates easier navigation and understanding of protein functional sites.
- It serves as a valuable tool for researchers in proteomics and bioinformatics.