Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetes and endothelial dysfunction: a clinical perspective.

J Calles-Escandon1, M Cipolla

  • 1Department of Internal Medicine, College of Medicine, University of Vermont, Burlington 05401, USA. jcallese@zoo.uvm.edu

Endocrine Reviews
|February 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis.

Neurogastroenterology and motility·2017
Same author

Childhood osteosarcoma: Incidence and survival in Argentina. Report from the National Pediatric Cancer Registry, ROHA Network 2000-2013.

Pediatric blood & cancer·2017
Same author

Baseline features and differences in 48 week clinical outcomes in patients with gastroparesis and type 1 vs type 2 diabetes.

Neurogastroenterology and motility·2016
Same author

Which are important targets in development of S. aureus mastitis vaccine?

Research in veterinary science·2015
Same author

Short communication: study on veterinarian communication skills preferred and perceived by dairy farmers.

Research in veterinary science·2015
Same author

Indoor pollution and burning practices in wood stove management.

Journal of the Air & Waste Management Association (1995)·2014

Atherosclerosis, a major complication of diabetes mellitus, is linked to endothelial dysfunction. While some therapies show short-term benefits, long-term cardiovascular outcomes require further investigation for diabetes patients.

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Metabolic Disorders

Background:

  • Atherosclerosis is the primary cause of mortality and morbidity in diabetes mellitus.
  • Endothelial dysfunction, characterized by altered signaling or nitric oxide bioavailability, is hypothesized as an initial atherosclerotic lesion.
  • This dysfunction is observed in patients with diabetes, insulin resistance, and those at high risk for type 2 diabetes.

Purpose of the Study:

  • To review the role of endothelial dysfunction in diabetes-related atherosclerosis.
  • To evaluate the efficacy of various therapeutic interventions on endothelial function in diabetic patients.

Main Methods:

  • Literature review of clinical trials and studies investigating endothelial function in diabetes.
  • Analysis of factors contributing to endothelial dysfunction in diabetes, including protein kinase C activation, growth factor/cytokine overexpression, and oxidative stress.

Related Experiment Videos

  • Assessment of therapeutic interventions such as insulin sensitizers, ACE inhibitors, hypolipidemic agents, antioxidant therapy, and hormone replacement therapy.

    • Main Results:

    • Insulin sensitizers may offer short-term improvements, but cardiovascular endpoint data are lacking.
    • ACE inhibitors show promise in potentially slowing atherosclerosis progression.
    • The impact of hypolipidemic agents is unclear, antioxidant therapy is controversial, and hormonal replacement therapy data is absent for postmenopausal women with type 2 diabetes.

    Conclusions:

    • Endothelial dysfunction is a critical factor in diabetes-related atherosclerosis.
    • Further research with cardiovascular endpoints is needed to confirm the long-term benefits of therapeutic interventions.
    • Targeting endothelial dysfunction presents a potential strategy for managing cardiovascular complications in diabetes.