Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The somatomedin hypothesis: 2001.

D Le Roith1, C Bondy, S Yakar

  • 1Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892-1758, USA. derek@helix.nih.gov

Endocrine Reviews
|February 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2023
Same author

Review: Preference elicitation methods for appropriate breeding objectives.

Animal : an international journal of animal bioscience·2022
Same author

Carbon dioxide levels in neonates: what are safe parameters?

Pediatric research·2021
Same author

Characteristics of a later life population in a general adult community mental health service setting.

Irish journal of psychological medicine·2021
Same author

Imaging of adult intestinal failure.

Clinical radiology·2019
Same author

Imaging of intestinal transplantation.

Clinical radiology·2019

Normal growth in mice lacking liver-produced insulin-like growth factor-I (IGF-I) suggests other sources contribute to development. Further research is needed to clarify the role of local IGF-I signaling.

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Genetics

Background:

  • The original somatomedin hypothesis proposed pituitary GH controls growth via liver-produced IGF-I.
  • Discoveries indicate IGF-I is produced by most tissues, leading to debate on autocrine/paracrine vs. circulating IGF-I roles.
  • Transgenic and gene-deletion technologies are used to investigate IGF-I functions.

Purpose of the Study:

  • To investigate the role of liver-derived insulin-like growth factor-I (IGF-I) in postnatal growth and development.
  • To differentiate the contributions of circulating IGF-I versus locally produced IGF-I.

Main Methods:

  • Utilized a liver-specific igf-1 gene-deleted mouse model.
  • Analyzed postnatal growth and development parameters.

Related Experiment Videos

  • Measured circulating and free IGF-I levels, as well as IGF-binding protein levels.

    • Main Results:

    • Mice with liver-specific igf-1 deletion exhibited normal postnatal growth and development.
    • Circulating IGF-I and IGF-binding protein levels were markedly reduced.
    • Free IGF-I levels remained normal in these mice.

    Conclusions:

    • Normal growth in the absence of liver-derived IGF-I suggests alternative sources of free IGF-I are sufficient for postnatal development.
    • The precise contribution of autocrine/paracrine IGF-I signaling to overall growth requires further investigation.