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Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
Published on: April 14, 2016
Prevention of uremic bone disease using calcimimetic compounds
1Nephrological Department P, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, Copenhagen, DK-2100 Denmark. olgaard@rh.dk
Annual Review of Medicine
|February 13, 2001
Summary
Calcimimetics, drugs that activate the calcium-sensing receptor (CaR), effectively suppress parathyroid hormone (PTH) secretion. These compounds show promise in preventing renal osteodystrophy in chronic kidney disease patients.
Area of Science:
- Pharmacology
- Nephrology
- Endocrinology
Background:
- The calcium-sensing receptor (CaR) discovery enabled the development of calcimimetics.
- Calcimimetics are phenylalkylamine derivatives acting as CaR agonists.
- These drugs increase CaR sensitivity to extracellular calcium, impacting PTH levels.
Purpose of the Study:
- To investigate the effects of calcimimetics, specifically NPS R-568, on parathyroid hormone (PTH) secretion.
- To evaluate the therapeutic potential of calcimimetics in preventing renal osteodystrophy (RO) associated with chronic renal failure and secondary hyperparathyroidism (HPT).
Main Methods:
- Administration of NPS R-568 to experimental animals with chronic renal failure.
- Studies involving patients with chronic renal failure and secondary HPT.
- Observation of PTH levels, calcium levels, and RO development.
Main Results:
- NPS R-568 demonstrated an acute, dose-dependent, and short-lived suppressive effect on PTH secretion in animals and humans.
- Calcimimetics induced a slight degree of hypocalcemia.
- Beneficial effects on the prevention of RO were observed in rats with experimental chronic renal failure.
Conclusions:
- Calcimimetics show significant suppressive effects on PTH secretion, indicating therapeutic potential for RO in chronic uremia.
- Further human studies are ongoing to evaluate long-term benefits and adverse effects.
- Calcimimetics may be a valuable addition to current strategies like phosphate binders and vitamin D analogs.
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