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Mixed chimerism and transplantation tolerance.

T Wekerle¹, M Sykes

¹Department of Surgery, Vienna General Hospital, University of Vienna, Währingergürtel 18, Vienna, A-1090 Austria. Thomas.Wekerle@akh-wien.ac.at

Annual Review of Medicine

|February 13, 2001

Summary

Inducing mixed chimerism offers a path to lifelong transplant tolerance. Recent advancements have developed milder conditioning protocols, enabling success in large animals and paving the way for clinical application.

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Published on: August 12, 2017

Area of Science:

Immunology
Transplantation Biology
Regenerative Medicine

Background:

Organ transplantation aims to reduce recipient morbidity and mortality.
Donor-specific tolerance is crucial for long-term transplant success.
Current protocols face challenges due to conditioning toxicity and limited large animal studies.

Purpose of the Study:

To review recent progress in achieving transplantation tolerance via mixed chimerism.
To highlight the development of milder conditioning protocols.
To discuss the extension of these models to large animals and xenogeneic tolerance.

Main Methods:

Review of recent scientific literature on mixed chimerism and transplantation tolerance.
Analysis of advancements in conditioning protocols for rodents and large animals.
Examination of studies on xenogeneic tolerance induction.

Main Results:

Development of significantly milder conditioning protocols in rodent models.
Successful induction of permanent mixed chimerism and tolerance in large animals.
Progress in inducing xenogeneic tolerance through mixed chimerism.

Conclusions:

Milder conditioning protocols are advancing transplantation tolerance.
Mixed chimerism holds promise for clinical application in organ transplantation.
Further research in large animal models and xenotransplantation is warranted.