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Updated: Jul 31, 2026
13:33
Infinium Assay for Large-scale SNP Genotyping Applications
Published on: November 19, 2013
Diversity arrays: a solid state technology for sequence information independent genotyping
D Jaccoud1, K Peng, D Feinstein
1Center for the Application of the Molecular Biology to International Agriculture (CAMBIA) Canberra, ACT, Australia.
Nucleic Acids Research
|February 13, 2001
Summary
This study showcases Diversity Array Technology (DArT) for high-throughput DNA polymorphism analysis using the rice genome. DArT enables rapid, economical genetic fingerprinting for diverse organisms and genomic mixtures.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Microarray technology offers a platform for DNA polymorphism analysis.
- High-throughput genome analysis is crucial for understanding genetic diversity.
- The rice genome serves as a model for developing new genomic tools.
Purpose of the Study:
- To demonstrate the successful application of microarray technology for DNA polymorphism analysis.
- To present Diversity Array Technology (DArT) as a high-throughput genome analysis method.
- To showcase the utility of DArT for genetic fingerprinting.
Main Methods:
- Application of microarray technology to analyze DNA polymorphisms.
- Utilizing the rice genome as a model system.
- Developing and applying two DArT approaches: contrasting representations on a single array or with a reference DNA fragment.
Main Results:
- Successful application of DArT for DNA polymorphism analysis.
- Demonstrated potential of DArT for high-throughput genome analysis.
- Creation of Diversity Panels for genetic fingerprinting.
Conclusions:
- DArT is a powerful tool for rapid and economical genetic fingerprinting.
- The technology is applicable to any genome or complex genomic mixtures.
- Microarray-based DArT enables highly parallel, solid-state genotyping.
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