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Related Experiment Videos

Lamotrigine for central poststroke pain: a randomized controlled trial.

K Vestergaard1, G Andersen, H Gottrup

  • 1Department of Neurology, Aalborg Hospital, Aalborg, Denmark.

Neurology
|February 13, 2001
PubMed
Summary

Lamotrigine at 200 mg daily offers a moderately effective and well-tolerated treatment option for central poststroke pain (CPSP). This finding suggests lamotrigine as a potential alternative to tricyclic antidepressants for managing CPSP.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Central poststroke pain (CPSP) presents significant treatment challenges.
  • Current treatments like amitriptyline have limited efficacy and potential side effects.

Purpose of the Study:

  • To investigate the efficacy and tolerability of lamotrigine in treating central poststroke pain.
  • To evaluate lamotrigine as a potential alternative to existing therapies for CPSP.

Main Methods:

  • A randomized, double-blind, placebo-controlled cross-over study involving 30 patients with CPSP.
  • Patients received varying doses of lamotrigine (25-200 mg/d) or placebo over two 8-week periods with a 2-week wash-out.
  • Primary endpoint: median daily pain score at 200 mg/d lamotrigine.

Main Results:

Related Experiment Videos

  • Lamotrigine 200 mg/d significantly reduced median pain scores compared to placebo (p = 0.01).
  • Lower doses of lamotrigine did not show significant pain reduction.
  • 44% of patients responded to lamotrigine treatment, which was generally well-tolerated with mild side effects.

Conclusions:

  • Oral lamotrigine 200 mg daily is a moderately effective and well-tolerated treatment for central poststroke pain.
  • Lamotrigine presents a viable alternative to tricyclic antidepressants for CPSP management.