HIV-associated neurologic disease incidence changes:: Multicenter AIDS Cohort Study, 1990-1998
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Updated: Oct 9, 2026

A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
N Sacktor1, R H Lyles, R Skolasky
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sacktor@jhmi.edu
Abstract:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.
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