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Related Experiment Videos

Postoperative glycyl-glutamine infusion reduces immunosuppression: partial prevention of the surgery induced decrease

A Spittler1, T Sautner, A Gornikiewicz

  • 1Surgical Research Laboratories, AKH, University of Vienna, Wachringer Guertel 19-20, 1090 Vienna, Austria.

Clinical Nutrition (Edinburgh, Scotland)
|February 13, 2001
PubMed
Summary

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Postoperative glycyl-glutamine (GLY-GLN) infusions preserved monocyte HLA-DR expression after surgery, unlike alanyl-glutamine. This finding suggests GLY-GLN may help prevent infections in surgical patients.

Area of Science:

  • Immunology
  • Surgical Metabolism
  • Nutritional Support

Background:

  • Surgery, trauma, and inflammation decrease monocyte HLA-DR expression, increasing infection risk.
  • Postoperative plasma glutamine (GLN) levels decline, impacting monocyte function.
  • In vitro studies show GLN concentration influences HLA-DR expression on monocytes.

Purpose of the Study:

  • To investigate if postoperative infusions of glutamine dipeptides prevent decreased monocyte HLA-DR expression.
  • To compare the effects of glycyl-glutamine (GLY-GLN) and alanyl-glutamine (ALA-GLN) on postoperative HLA-DR expression.

Main Methods:

  • Thirty patients undergoing major abdominal surgery were studied.
  • Patients received either a control infusion or GLY-GLN or ALA-GLN (35g GLN) over 48 hours postoperatively.

Related Experiment Videos

  • Monocyte HLA-DR expression was measured by flow cytometry immediately and 48 hours after surgery.

    • Main Results:

    • GLY-GLN significantly preserved monocyte HLA-DR expression at 48 hours compared to controls (65.0% vs 42.5%).
    • ALA-GLN did not show a significant difference in preserving HLA-DR expression compared to controls.
    • Patient groups were comparable in age, gender, and operation time.

    Conclusions:

    • This is the first study to compare GLY-GLN and ALA-GLN in the postoperative setting.
    • GLY-GLN's ability to preserve monocyte HLA-DR expression may help prevent postoperative infectious complications.