Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Permanently infertile couples and family building-a cross-sectional survey in Denmark.

Human reproduction (Oxford, England)·2024

Same author

Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases.

Ageing research reviews·2021

Same author

First detection of gas bubble disease and Rickettsia-like organisms in Paphies ventricosa, a New Zealand surf clam.

Journal of fish diseases·2017

Same author

Nocardiosis in freshwater reared Chinook salmon (Oncorhynchus tshawytscha).

New Zealand veterinary journal·2017

Same author

A case report of Plasmodium vivax, Plasmodium falciparum and dengue co-infection in a 6 months pregnancy.

Annals of medical and health sciences research·2013

Same author

miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.

Oncogene·2013

Search research articles

Related Experiment Video

Updated: Jul 21, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

PANORAMA: an integrated Web-based sequence analysis tool and its role in gene discovery.

A Pertsemlidis¹, A Pande, B Miller

¹Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

|February 13, 2001

Summary

The PANORAMA software package offers integrated sequence analysis and visualization for DNA data. It aids in discovering genes, splice forms, and regulatory elements in genomic regions, enhancing cancer research.

More Related Videos

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Introductory Analysis and Validation of CUT&RUN Sequencing Data

Introductory Analysis and Validation of CUT&RUN Sequencing Data

Published on: December 13, 2024

Related Experiment Videos

Last Updated: Jul 21, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Introductory Analysis and Validation of CUT&RUN Sequencing Data

Introductory Analysis and Validation of CUT&RUN Sequencing Data

Published on: December 13, 2024

Area of Science:

Bioinformatics
Genomics
Computational Biology

Background:

Exponential growth of DNA sequence data necessitates advanced analysis tools.
Integrating sequence analysis and visualization is crucial for knowledge discovery.
The human chromosome region 3p21.3 is implicated in various cancers.

Purpose of the Study:

To introduce PANORAMA, an Internet-accessible software package for integrative sequence analysis and visualization.
To demonstrate PANORAMA's utility in analyzing a specific human genomic region.

Main Methods:

PANORAMA performs various informatics analyses on DNA sequences.
It provides visual and interactive representations of analysis results.
The software is designed modularly for easy integration of new tools.

Main Results:

PANORAMA facilitated the analysis of 650 kb of human genomic DNA from chromosome region 3p21.3.
It aided in discovering genes, alternate splice forms, and intron-exon boundaries.
Identification of promoter regions and polymorphisms was also achieved.

Conclusions:

PANORAMA enhances the understanding of complex genomic regions.
The tool supports the identification of potential tumor suppressor genes.
PANORAMA is a valuable resource for genomic research and cancer studies.