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[Liver function in undisturbed pregnancy].

H Schlebusch, K Schander, M Sorger

    Fortschritte Der Medizin
    |November 18, 1976
    PubMed
    Summary
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    Liver function in pregnancy is generally stable, with normal enzyme levels for GPT, GOT, and others. Only alkaline phosphatase (AP) and leucine aminopeptidase (LAP) enzyme activities increase due to placental synthesis.

    Area of Science:

    • Biochemistry
    • Hepatology
    • Obstetrics

    Context:

    • Evaluating liver function is crucial during pregnancy.
    • Pregnancy imposes unique physiological demands on maternal organs.
    • Assessing liver enzyme profiles helps monitor maternal and fetal health.

    Purpose:

    • To determine the normal ranges of key liver enzymes during pregnancy.
    • To identify pregnancy-specific alterations in liver enzyme activities.
    • To differentiate physiological from pathological changes in liver function during gestation.

    Summary:

    • This study analyzed 272 healthy pregnant women, measuring enzyme activities including GPT, GOT, GLDH, LDH, AP, LAP, gamma-GT, and CHE from the 16th week to term.
    • Normal ranges for GPT, GOT, GLDH, LDH, gamma-GT, and CHE remained consistent with non-pregnant levels.

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  • Elevated alkaline phosphatase (AP) and leucine aminopeptidase (LAP) were observed, attributed to placental synthesis, indicating these are physiological adaptations.

    • Impact:

    • Establishes reference ranges for liver enzymes in pregnant women.
    • Highlights normal physiological changes in AP and LAP during pregnancy.
    • Provides a basis for identifying abnormal liver function in pregnant individuals.