Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphologic changes in the aorta during elastase infusion in the rat aneurysm model.

T Yamaguchi1, M Yokokawa, M Suzuki

  • 1First Department of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan. surg1@ms.toyama-mpu.ac.jp

The Journal of Surgical Research
|February 13, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insulin administration induces capillary growth in brown adipose tissue of heat-exposed rats.

Comparative biochemistry and physiology. Comparative physiology·1992
Same author

[A study of falls experienced by institutionalized elderly].

[Nihon koshu eisei zasshi] Japanese journal of public health·1992
Same author

Two types of septic shock classified by the plasma levels of cytokines and endotoxin.

Circulatory shock·1992
Same author

Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4.

Journal of biochemistry·1992
Same author

A retrospective study on delirium type.

The Japanese journal of psychiatry and neurology·1992
Same author

Effect of multiple irradiation with low doses of gamma-rays on morphological transformation and growth ability of human embryo cells in vitro.

International journal of radiation biology·1992

Elastase infusion in rats shows aortic morphologic changes complete by 60 minutes. This suggests reducing infusion time in the abdominal aortic aneurysm model may be possible.

Area of Science:

  • Vascular Biology
  • Biomedical Engineering

Background:

  • Investigated morphologic changes in the aorta during elastase infusion.
  • Utilized the rat abdominal aortic aneurysm model.

Purpose of the Study:

  • To examine the time course of aortic morphologic changes induced by elastase infusion.
  • To determine the minimum effective elastase infusion duration in a rat model.

Main Methods:

  • Administered elastase infusion to Wistar rats for varying durations (10, 20, 30, 60, 120 minutes).
  • Assessed aortic transparency and diameter during infusion.
  • Performed histologic examination of excised aortas post-infusion.
  • Measured aortic diameters 7 days after infusion.

Main Results:

Related Experiment Videos

  • Aortic transparency was observed within 50 minutes of elastase infusion.
  • Significant aortic diameter increase occurred within the first 30 minutes.
  • Complete loss of elastic tissue was evident after 60 minutes of infusion.
  • No significant difference in aortic diameter was found between 60- and 120-minute infusion groups at 7 days.

Conclusions:

  • Morphologic alterations in the aorta due to elastase infusion are complete by 60 minutes.
  • The elastase infusion duration in this model can potentially be reduced from 120 to 60 minutes.