Biochemical engineering of natural product biosynthesis pathways
1Natural Products Drug Discovery-Microbiology, Merck Research Labs, Rahway, New Jersey 07065, USA. william_strohl@merck.com
Abstract:
Metabolic engineering of natural products is a science that has been built on the goals of traditional strain improvement with the availability of modern molecular biological technologies. In the past 15 years, the state of the art in metabolic engineering of natural products has advanced from the first proof-of-principle experiment based on minimal known genetics to a commonplace event using highly specific and sophisticated gene manipulation methods. With the availability of genes, host organisms, vector systems, and standard molecular biological tools, it is expected that metabolic engineering will be translated into industrial reality.
More Related Videos
09:08From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
07:59A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Related Concept Videos
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Biosynthesis in Bacteria
Amino Acid Biosynthetic Pathways
Bioreactor Controls-III
Production of Antibiotics
Production of Pharmaceuticals
