Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural analysis and mutation detection strategy for the human LAMC3 gene.

P B Cserhalmi-Friedman1, P F Olson, M Koch

  • 1Department of Dermatology, Columbia University, 630 West 168th Street VC-1526, New York, New York 10032, USA.

Biochemical and Biophysical Research Communications
|February 13, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the overlap between alopecia areata and major depressive disorder: Epidemiological and genetic perspectives.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

Genomic profiling of late-onset basal cell carcinomas from two brothers with nevoid basal cell carcinoma syndrome.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Authors' reply to: Comment on the article by Dr. Toshima about alopecia areata multiplex following autologous dermal micrograft injection.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Alopecia areata multiplex following autologous dermal micrograft injection for treatment of androgenetic alopecia.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis.

The Journal of investigative dermatology·2018
Same author

Identification of differentially expressed miRNAs in alopecia areata that target immune-regulatory pathways.

Genes and immunity·2017

Researchers studied the LAMC3 gene, which encodes laminin gamma3. This investigation aimed to understand laminin gamma3

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Laminins are crucial extracellular matrix proteins forming basement membranes in human tissues.
  • Laminins are heterotrimeric molecules composed of alpha, beta, and gamma subunits.
  • Three gamma subunits exist: gamma1, gamma2 (in basement membranes), and gamma3 (found in various tissues and specific cell surfaces).

Purpose of the Study:

  • To investigate the function and potential role of laminin gamma3 in human diseases.
  • To elucidate the genomic organization of the LAMC3 gene, which encodes laminin gamma3.
  • To develop a mutation detection strategy for genetic studies involving LAMC3.

Main Methods:

  • Genomic organization analysis of the LAMC3 gene.
  • Development of a mutation detection strategy for genetic studies.

Related Experiment Videos

Main Results:

  • The genomic organization of the LAMC3 gene was elucidated.
  • A strategy for detecting mutations in the LAMC3 gene was established.

Conclusions:

  • Understanding the LAMC3 gene structure and developing mutation detection methods are essential for further research into laminin gamma3 function and its role in human disease.