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Influence of myocardial infarction on serum manganese, copper, and zinc concentrations
Abstract:
Reportedly, serum manganese concentrations increase after myocardial infarction, closely correlated with increased serum aspartate aminotransferase activity. However, these conclusions are apparently based on analyses of contaminated samples. Serum manganese concentrations after myocardial infarction have been re-investigated by neutron activation analysis, and no significant increase could be demonstrated. Because serum copper and zinc could be determined simultaneously, analyses for these trace elements are also reported, which confirm the findings of others. After myocardial infarction a statistically significant (0.02 smaller than P smaller than 0.05) increase in serum copper and a statistically significant (0.001 smaller than P smaller than 0.01) decrease in serum zinc were observed.
Insights
This study found no significant increase in serum manganese after myocardial infarction, correcting previous findings. However, significant increases in serum copper and decreases in serum zinc were observed in patients.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Trace Element Analysis
Background:
- Previous studies suggested elevated serum manganese post-myocardial infarction, linked to aspartate aminotransferase activity.
- These earlier findings may be attributed to sample contamination issues.
- Accurate trace element analysis is crucial for understanding myocardial infarction pathophysiology.
Purpose of the Study:
- To re-evaluate serum manganese levels in patients following myocardial infarction.
- To investigate concurrent changes in serum copper and zinc concentrations after myocardial infarction.
- To clarify the role of trace elements in myocardial infarction using precise analytical methods.
Main Methods:
- Neutron activation analysis was employed for precise quantification of serum manganese.
- Simultaneous analysis of serum copper and zinc was performed.
- Statistical analysis was conducted to determine the significance of observed changes.
Main Results:
- No statistically significant increase in serum manganese was detected after myocardial infarction.
- A statistically significant increase in serum copper concentrations was observed (0.02 < P < 0.05).
- A statistically significant decrease in serum zinc concentrations was observed (0.001 < P < 0.01).
Conclusions:
- The previously reported increase in serum manganese after myocardial infarction is likely due to analytical errors from contaminated samples.
- Serum copper and zinc levels show significant alterations post-myocardial infarction, with copper increasing and zinc decreasing.
- These findings highlight the importance of accurate trace element measurement in cardiovascular research and diagnostics.