Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extraversion. Interaction between D2 dopamine receptor polymorphisms and parental alcoholism.

T Ozkaragoz1, E P Noble

  • 1Department of Psychiatry and Biobehavioral, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024-1759, USA.

Alcohol (Fayetteville, N.Y.)
|February 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain-specific epigenetic markers of schizophrenia.

Translational psychiatry·2015
Same author

Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients.

Translational psychiatry·2014
Same author

DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia.

Journal of psychopharmacology (Oxford, England)·2012
Same author

The DRD2A₁allele: a behavioural genetic risk factor in hepatitis C infection of persistent drug abusers.

Addiction biology·2010
Same author

Advances in molecular genetics and the prevention and treatment of substance misuse: Implications of association studies of the A1 allele of the D2 dopamine receptor gene.

Addictive behaviors·2004
Same author

Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele.

Alcohol and alcoholism (Oxford, Oxfordshire)·2002

This study explored gene-environment interactions in adolescent personality. A significant interaction between dopamine D2 receptor (DRD2) gene and home environment influenced Extraversion in boys.

Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Developmental Psychology

Background:

  • Personality traits like Extraversion and Neuroticism are influenced by genetic and environmental factors.
  • Dopamine receptor genes (DRD2, DRD4) are implicated in behavioral regulation.
  • Adolescence is a critical period for personality development and gene-environment interplay.

Purpose of the Study:

  • To investigate the main effects of DRD2 and DRD4 gene polymorphisms and growing up in an alcoholic versus nonalcoholic home on personality traits.
  • To examine potential gene-environment interactions on Extraversion and Neuroticism in drug-naive adolescent boys.

Main Methods:

  • Assessed personality traits using the Junior Eysenck Personality Inventory (JEPI).
  • Genotyped dopamine receptor D2 (DRD2) and D4 (DRD4) polymorphisms.

Related Experiment Videos

  • Compared personality scores based on genetic variations and home environment (alcoholic vs. nonalcoholic).

    • Main Results:

    • No significant main effects of genetic or environmental factors on Neuroticism or Extraversion.
    • A significant interaction was found between DRD2 alleles and home environment on Extraversion.
    • Adolescents with minor DRD2 alleles showed higher Extraversion in alcoholic homes compared to nonalcoholic homes.

    Conclusions:

    • This study provides preliminary evidence for a specific gene-environment interaction influencing human personality.
    • The DRD2 gene may moderate the effect of early life environment on Extraversion.
    • Further replication studies are needed to confirm these findings on personality development.