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Conformational changes during kinesin motility
1Department of Physiology & Biophysics, University of Washington, Box 357290, Seattle, Washington 98195-2790, USA. schief@u.washington.edu
Current Opinion in Cell Biology
|February 13, 2001
Abstract:
Nucleotide-dependent movements of the head and neck of kinesin have been visualized by cryoelectron microscopy and have been inferred from single-molecule studies. Key predictions of the hand-over-hand model for dimeric kinesin have been confirmed, and a novel processivity mechanism for the one-headed, kinesin-related motor KIF1A has been discovered.