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Updated: Aug 11, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Published on: June 6, 2017
Mitotic checkpoints: from yeast to cancer
1Cell Biology Program, Memorial Sloan-Kettering Cancer Center and the Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, Box 241, 1275 York Avenue, New York, New York 10021, USA.
Abstract:
Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.
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