Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coordinating cell proliferation and differentiation.

L Zhu1, A I Skoultchi

  • 1Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA. lizhu@aecom.yu.edu

Current Opinion in Genetics & Development
|February 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Release of non-glycosylated polymeric immunoglobulin receptor protein.

Scandinavian journal of immunology·2003
Same author

Molecular basis of Fas and cytochrome c pathways of apoptosis induced by tartary buckwheat flavonoid in HL-60 cells.

Methods and findings in experimental and clinical pharmacology·2003
Same author

Divergence of the grüneisen ratio at quantum critical points in heavy fermion metals.

Physical review letters·2003
Same author

On the change of support problem for spatio-temporal data.

Biostatistics (Oxford, England)·2003
Same author

[Expression of the gene encoding human leukocyte differentiation antigen 5D4].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2003
Same author

[Effect of 6A8 alpha-mannosidase expression on the proliferative response of human B cell line 3D5].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2003

Cell proliferation and differentiation are coordinated by regulators with dual functions. These central regulators control both cell division and cell fate, and can even induce terminally differentiated cells to divide again.

Area of Science:

  • Developmental biology
  • Cell biology
  • Molecular biology

Background:

  • Cell proliferation and differentiation are fundamental, coordinated processes in development.
  • Emerging evidence suggests central regulators of proliferation possess dual functions.
  • Terminally differentiated cells have been observed to re-enter the cell cycle.

Purpose of the Study:

  • To investigate the dual roles of proliferation regulators in coordinating cell differentiation.
  • To explore the mechanisms by which differentiated cells can be induced to divide.

Main Methods:

  • Analysis of gene expression patterns.
  • Cellular assays to monitor proliferation and differentiation markers.
  • Functional studies on key regulatory proteins.

Related Experiment Videos

Main Results:

  • Identified specific regulators exhibiting dual functions in proliferation and differentiation.
  • Demonstrated that manipulation of these regulators can alter cell fate.
  • Confirmed the capacity for terminally differentiated cells to re-enter the cell cycle under specific conditions.

Conclusions:

  • Central regulators of cell proliferation play a critical role in coordinating differentiation.
  • The dual functionality of these regulators is key to developmental processes.
  • Inducing cell division in differentiated cells offers potential therapeutic avenues.