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Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Haemodynamic changes during beating heart coronary surgery with the 'Bristol Technique'
M P Watters1, R Ascione, I G Ryder
1Bristol Heart Institute, Bristol Royal Infirmary, BS2 8HW, Bristol, UK.
Insights
Off-pump coronary artery bypass surgery requires precise vessel stabilization. While some hemodynamic changes occur during grafting of the circumflex and posterior descending arteries, they are transient and well-tolerated.
Area of Science:
- Cardiovascular Surgery
- Cardiac Anesthesia
- Hemodynamics
Background:
- Optimal exposure and stabilization of coronary arteries are crucial for precise anastomosis during off-pump coronary artery bypass (OPCAB) surgery.
- However, surgical manipulation can lead to significant hemodynamic deterioration, especially when grafting the circumflex (Cx) and posterior descending arteries (PDA).
Purpose of the Study:
- To assess the hemodynamic changes associated with positioning the beating heart for grafting the three main coronary arteries (left anterior descending - LAD, PDA, and Cx) during OPCAB surgery.
Main Methods:
- Twenty-nine patients undergoing OPCAB surgery were studied.
- Three surgical setups were used for LAD, PDA, and Cx anastomoses.
- Hemodynamic parameters were recorded at baseline and after each distal anastomosis with the heart in its anatomical position.
Main Results:
- No significant changes in heart rate (HR) or mean arterial pressure were observed across all setups.
- Grafting the LAD (setup 1) resulted in a decrease in stroke volume (SV) and an increase in pulmonary capillary wedge pressure (PCWP).
- Grafting the PDA (setup 2) and Cx (setup 3) led to more pronounced decreases in SV and cardiac index (CI), along with increases in central venous pressure (CVP), PCWP, pulmonary arterial pressure, and systemic vascular resistance index (SVRI).
- These hemodynamic changes were transient and resolved upon returning the heart to its anatomical position.
Conclusions:
- Exposure and stabilization of the three main coronary arteries during beating heart surgery do not cause significant changes in systemic blood pressure and HR.
- Transient hemodynamic deterioration during Cx and PDA distal anastomoses is well-tolerated, with no reported adverse clinical events.
Objectives:
Optimal exposure and stabilization of the target coronary vessel is essential to allow the construction of a precise coronary anastomosis during off pump coronary surgery. However, this might be achieved at the expense of significant haemodynamic deterioration, particularly while grafting the circumflex and the posterior descending coronary arteries. The present study was designed to assess the haemodynamic changes with the beating heart positioned for grafting the three main coronaries.
Methods:
Twenty-nine consecutive patients (21 male, mean age 62.6+/-7.1 years) undergoing off pump coronary surgery were enrolled in the study. Three different surgical settings of exposure and stabilization were used according to the site of anastomosis: left anterior descending (LAD - set-up 1; n=29), posterior descending (PDA - set-up 2; n=15), and circumflex (Cx - set-up 3; n=21) coronary arteries. Haemodynamic measurements were recorded before any cardiac manipulation (baseline) in set-ups 1, 2 and 3, and immediately after the completion of each distal anastomosis with the heart returned to its anatomical position.
Results:
There were no marked changes in heart rate (HR) and systemic mean arterial pressure during the construction of the anastomoses for any of the three surgical settings. Set-up 1 (LAD) showed a decrease of 15.5% in stroke volume (SV) and an increase of 9% in pulmonary capillary wedge pressure (PCWP) compared to baseline (both P<0.05), with all the other haemodynamic parameters remaining unchanged. Set-up 2 (PDA) showed a marked decrease in SV and cardiac index (CI), and an increase in central venous pressure (CVP) when compared to baseline (all P<0.05). The most extensive changes were observed in set-up 3 (Cx) with a considerable reduction in SV and CI, and an increase in CVP, PCWP, pulmonary arterial pressure, and systemic vascular resistance index (all P<0.05). These haemodynamic changes were transient and totally recovered after the heart was returned to its anatomical position.
Conclusions:
Exposure and stabilization of the three main coronary arteries during beating heart surgery does not produce any appreciable change in systemic blood pressure and HR. The haemodynamic deterioration observed during the construction of the circumflex and posterior descending coronary arteries distal anastomoses is transient and well tolerated with no adverse clinical events.
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