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Updated: Oct 9, 2026
Detection of Rabies IgG and IgM Antibodies Using the Rabies Indirect Fluorescent Antibody Test
Published on: January 19, 2024
Immunologic and virologic evaluation of HIV-1-infected children after rabies vaccination
U Thisyakorn1, C Pancharoen, H Wilde
1Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, 10330, Bangkok, Thailand.
Background:
One-third of Thai children experience a dog bite by the time they are 15 years old, and HIV-1 infection in children is also not uncommon. Previous study has shown that rabies vaccination of HIV-1-infected children may not result in a satisfactory antibody response when CD4+ T cells are less than 15%. The objective of this prospective clinical study is to evaluate the immunologic response and effect on viral load after rabies vaccination in HIV-infected children.
Methods:
Thirteen HIV-1-infected children were vaccinated with the intramuscular rabies pre-exposure regimen using human diploid cell rabies vaccine (HDCV) on days 0, 7 and 28. CD4+ and CD8+ lymphocyte counts were performed on days 0, 7 and 28. Plasma viral loads were determined on days 0, 7, 14, 60, 90, 180 and 360.
Results:
There were no significant change in serial measurements of CD4+/CD8+ lymphocytes during a period of 1 month and in plasma viral load during 1 year. There was no associated clinical deterioration or any adverse reactions attributable to vaccine.
Conclusions:
Rabies vaccination in HIV-1-infected children appears to be safe but did not significantly change the levels of plasma HIV RNA, CD4+ and CD8+ cell counts.
