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Synthesis and in vitro evaluation of 123I-labelled human recombinant annexin V
C Lahorte1, G Slegers, J Philippé
1Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Harelbekestraat 72, B-9000, Ghent, Belgium. christophe.lahorte@rug.ac.be
Biomolecular Engineering
|February 13, 2001
Abstract:
Annexin V was radiolabelled with iodine-123 in order to develop a SPECT-ligand for imaging atherosclerosis and apoptosis. Iodination by means of electrophylic substitution resulted in radiochemical yields up to 70% and specific activities of 7.4-92.5 MBq/microg protein. Binding experiments with blood platelets indicated that 123I-labelled annexin V remained its biological activity.