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Increased microvessel density in adenomyosis uteri
M Schindl1, P Birner, A Obermair
1Department of Gynecology and Obstetrics, University of Vienna, Vienna, Austria. monika.schindl@akh-wien.ac.at
Fertility and Sterility
|February 13, 2001
Summary
Adenomyosis tissue shows increased microvessel density, indicating angiogenic properties. However, the endometrium in adenomyosis patients does not exhibit higher angiogenic activity than normal controls.
Area of Science:
- Gynecopathology
- Reproductive Medicine
- Angiogenesis Research
Background:
- Adenomyosis is a condition characterized by the presence of endometrial tissue within the myometrium.
- Microvessel density is a potential indicator of angiogenic activity in various tissues.
Purpose of the Study:
- To compare microvessel density in adenomyosis tissue versus the endometrium of patients with adenomyosis.
- To evaluate the endometrium of adenomyosis patients against normal controls for angiogenic differences.
Main Methods:
- Histologic specimens from 53 adenomyosis patients and 17 controls were immunostained for CD34.
- Microvessel density was quantified in adenomyosis and endometrial tissue at x200 magnification.
Main Results:
- Microvessel density was significantly higher in adenomyosis tissue compared to the endometrium of the same patients (33.5 vs. 19.5 microvessels/field; P<.001).
- No significant difference in microvessel density was found between the endometrium of adenomyosis patients and normal controls (P=.805).
Conclusions:
- Adenomyosis demonstrates inherent angiogenic properties.
- The endometrium in adenomyosis patients does not show increased angiogenic activity compared to healthy controls.