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Related Experiment Videos

Amoxycillin release from a floating dosage form based on alginates.

L Whitehead1, J H Collett, J T Fell

  • 1School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK.

International Journal of Pharmaceutics
|February 13, 2001
PubMed
Summary

Floating alginate beads containing amoxycillin were developed for sustained drug release. Adding amylose enhanced release control, while suspended amoxycillin increased drug loading but reduced buoyancy.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Alginate beads are widely used for drug delivery.
  • Controlling drug release and buoyancy is crucial for effective delivery systems.

Purpose of the Study:

  • To develop buoyant alginate beads for amoxycillin delivery.
  • To investigate the impact of drug formulation (dissolved vs. suspended) and amylose addition on drug release and bead buoyancy.

Main Methods:

  • Alginate solutions with dissolved or suspended amoxycillin were prepared.
  • Beads were formed by dropwise addition into calcium chloride solution.
  • Freeze-drying was employed for bead processing.
  • Drug release and buoyancy were evaluated over 20 hours.

Main Results:

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  • Dissolved amoxycillin in alginate beads showed sustained release, improved by amylose.
  • Drug release followed a solute release pattern from a porous matrix.
  • Buoyancy was maintained, with weight greater than zero after 20 hours.
  • Suspended amoxycillin allowed higher drug loading but resulted in faster release and reduced buoyancy.

Conclusions:

  • Buoyant alginate beads can be prepared for amoxycillin delivery.
  • Amylose addition is a viable strategy to enhance sustained release characteristics.
  • Formulation choices significantly impact drug loading, release kinetics, and buoyancy.