Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptotic capability in ageing T cells.

J D McLeod1

  • 1Centre for Research in Biomedicine, Faculty of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK. julie.mcleod@uwe.ac.uk

Mechanisms of Ageing and Development
|February 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An 'omics' approach towards the characterisation of laboratory scale anaerobic digesters treating municipal sewage sludge.

Water research·2015
Same author

Inter-laboratory study of the in vitro dendritic cell migration assay for identification of contact allergens.

Toxicology in vitro : an international journal published in association with BIBRA·2011
Same author

Lack of activation induced cell death in human T blasts despite CD95L up-regulation: protection from apoptosis by MEK signalling.

Immunology·1999
Same author

IL-2-independent activation and proliferation in human T cells induced by CD28.

Journal of immunology (Baltimore, Md. : 1950)·1999
Same author

Positive and negative regulation of human T cell activation mediated by the CTLA-4/CD28 ligand CD80.

Journal of immunology (Baltimore, Md. : 1950)·1998
Same author

Down-regulation of CD28 via Fas (CD95): influence of CD28 on T-cell apoptosis.

Immunology·1998
Same journal

Human sex-specific hormone effects on cerebrovascular health in males and females.

Mechanisms of ageing and development·2026
Same journal

HTZ-1/H2A.Z expression sustains transcriptional programs that regulate Caenorhabditis elegans lifespan.

Mechanisms of ageing and development·2026
Same journal

PCSK9 promotes aging-related cardiac calcification by inducing osteogenic differentiation of cardiac fibroblasts.

Mechanisms of ageing and development·2026
Same journal

Distinct post-infectious TLR2 immune remodeling in COVID-19-recovered centenarians.

Mechanisms of ageing and development·2026
Same journal

Senescence-associated tertiary lymphoid structures in Sjögren's disease model nishiura mice.

Mechanisms of ageing and development·2026
Same journal

Aging-driven reprogramming of CD34⁺ hematopoietic stem cells in leukemogenesis: Mechanisms and therapeutic implications.

Mechanisms of ageing and development·2026
See all related articles

Aging T cells exhibit increased susceptibility to apoptosis, a programmed cell death process crucial for immune regulation. This age-related decline in T cell function, known as immunosenescence, impacts immune surveillance and response to antigens and tumors.

Area of Science:

  • Immunology
  • Cell Biology
  • Gerontology

Background:

  • The aging immune system, termed immunosenescence, is characterized by a reduced responsiveness to antigens and tumors.
  • T cell functions, including activation, anergy, and apoptosis, are significantly altered with age.
  • Apoptosis is critical for maintaining immune homeostasis by regulating cell numbers and eliminating self-reactive cells.

Purpose of the Study:

  • To review current knowledge on the apoptotic susceptibility of aging T cells.
  • To evaluate factors influencing the apoptotic capacity of immunosenescent T cells.

Main Methods:

  • Literature review focusing on T cell apoptosis and immunosenescence.
  • Analysis of the CD95:CD95-ligand pathway in aging T cells.

Related Experiment Videos

Main Results:

  • Aging T cells display increased susceptibility to apoptosis.
  • Both CD95 receptor and CD95-ligand levels increase on aging T cells.
  • The CD95:CD95-ligand interaction is a key mediator of apoptosis in T cells.

Conclusions:

  • Immunosenescence leads to altered T cell apoptosis.
  • Increased CD95:CD95-ligand expression contributes to T cell apoptotic susceptibility.
  • Understanding these changes is vital for addressing age-related immune dysfunction.