Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitric oxide modulates lithium-induced conditioned taste aversion.

G Wegener1, V Volke, Z Bandpey

  • 1Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Skovagervej 2, DK-8240, Risskov, Denmark. wegener@dadlnet.dk

Behavioural Brain Research
|February 13, 2001
PubMed
Summary

Nitric oxide (NO) and serotonin (5-HT) systems influence conditioned taste aversion (CTA) learning. NO-modifying drugs, serotonergic drugs, and lithium all induced CTAs, suggesting complex interactions in avoidance learning.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How Is Colorectal Cancer Care Impacted by Global Crisis in Contrasting Healthcare Systems?-A Descriptive Study From Scotland and Switzerland During the COVID-19 Pandemic.

World journal of surgery·2026
Same author

Self-reported financial difficulties of colorectal cancer patients 1 year after start of treatment.

ESMO open·2025
Same author

The outcomes of robotic ileocolic resection in Crohn's disease compared with laparoscopic and open surgery: a meta-analysis and systematic review.

Techniques in coloproctology·2025
Same author

Quality of life with diverticular disease: translation and validation of the German version of the diverticulitis quality of life questionnaire (DV-QOL).

Techniques in coloproctology·2024
Same author

Case report: 65-year-old man with metachronous left sided adrenal metastasis of hepatocellular carcinoma.

International journal of surgery case reports·2024
Same author

[Loss of domain and reduction in median suture tension].

Chirurgie (Heidelberg, Germany)·2023

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Nitric oxide (NO) influences behaviors in animal models of depression, anxiety, and avoidance learning.
  • Lithium significantly impacts avoidance learning, with modulation possible via the serotonin (5-HT) system.

Purpose of the Study:

  • To investigate the role of NO-modifying and serotonergic drugs, along with lithium, in inducing or affecting conditioned taste aversion (CTA).
  • To explore potential interactions between the 5-HT and NO systems in the context of avoidance learning.

Main Methods:

  • Utilized the conditioned taste aversion (CTA) paradigm in animal models.
  • Administered NO-precursor L-arginine (L-Arg), NOS inhibitors (methylene blue, 7-Nitroindazole), lithium chloride (LiCl), and 5-HT drugs (8-OH-DPAT, p-Chlorophenylalanine).

Related Experiment Videos

  • Assessed the induction and modulation of CTAs by these agents, alone and in combination.

    • Main Results:

    • L-arginine, methylene blue, and 7-Nitroindazole dose-dependently induced CTAs.
    • L-arginine counteracted LiCl- and methylene blue-induced CTAs but not 7-NI-induced CTA.
    • The 5-HT1A agonist 8-OH-DPAT counteracted methylene blue- and 7-NI-induced CTAs, while 5-HT depletion counteracted L-Arg-induced CTA.

    Conclusions:

    • NO appears to play a role in the acquisition of LiCl-induced CTA.
    • The 5-HT1A receptor is crucial for CTAs induced by methylene blue and 7-NI.
    • Evidence suggests a significant interaction between the 5-HT and NO systems in avoidance learning.