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Improving the catalytic performance of peroxidases in organic synthesis
F van de Velde1, F van Rantwijk, R A Sheldon
1Nizo Food Research, PO Box 20, 6710 BA, Ede, The Netherlands.
Trends in Biotechnology
|February 13, 2001
Abstract:
Peroxidases are ubiquitous enzymes that catalyze a variety of enantioselective oxygen-transfer reactions with hydrogen peroxide (H2O2). Although they have enormous potential, their industrial application is hampered by their high price and low operational stability. Recent developments, such as the controlled addition and in situ formation of the oxidant, protein engineering and the rational design of semi-synthetic peroxidases, aim to improve the operational stability of peroxidases.