Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IgE adjuvant effect caused by particles - immediate and delayed effects.

B Granum1, P I Gaarder, M Løvik

  • 1Department of Environmental Medicine, National Institute of Public Health, P.O. Box 4404 Nydalen, Torshov, N-0403 Oslo, Norway. berit.granum@folkehelsa.no

Toxicology
|February 13, 2001
PubMed
Summary

Exposure to simple polystyrene particles (PSP) significantly increases allergen-specific IgE antibody production in mice. This particle adjuvant effect enhances allergic responses, even when allergen exposure occurs days after particle exposure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Filaggrin mutations in relation to skin barrier and atopic dermatitis in early infancy.

The British journal of dermatology·2021
Same author

Perfluoroalkyl substances, airways infections, allergy and asthma related health outcomes - implications of gender, exposure period and study design.

Environment international·2019
Same author

Maternal levels of perfluoroalkyl substances (PFASs) during pregnancy and childhood allergy and asthma related outcomes and infections in the Norwegian Mother and Child (MoBa) cohort.

Environment international·2019
Same author

Prenatal exposure to perfluoralkyl substances (PFASs) associated with respiratory tract infections but not allergy- and asthma-related health outcomes in childhood.

Environmental research·2017
Same author

Assessment of endogenous allergenicity of genetically modified plants exemplified by soybean - Where do we stand?

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2017
Same author

IgE Adjuvant Activity of Particles-What Physical Characteristics are Important?

Inhalation toxicology·2015

Area of Science:

  • Immunology
  • Environmental Health

Background:

  • Diesel exhaust particles are known to enhance allergic responses to allergens like ovalbumin (OVA) and pollen.
  • The particle core is implicated in the adjuvant activity, suggesting simple particles may also influence IgE production.

Purpose of the Study:

  • To investigate the adjuvant effect of well-defined simple particles, specifically polystyrene particles (PSP), on allergen-specific IgE production.
  • To determine if PSP can augment IgE responses to ovalbumin (OVA) in a mouse model.

Main Methods:

  • Mice were exposed to PSP via intranasal, intratracheal, or intraperitoneal routes.
  • Delayed and cumulative adjuvant effects were assessed by varying the timing of PSP administration relative to OVA exposure.
  • Levels of allergen-specific and total IgE were quantified.

Related Experiment Videos

Main Results:

  • Irrespective of the administration route and protocol, co-administration of PSP with OVA significantly increased both allergen-specific and total IgE levels compared to OVA alone.
  • PSP demonstrated a delayed and cumulative adjuvant effect, augmenting IgE responses even when OVA was introduced days after particle exposure.

Conclusions:

  • Polystyrene particles act as potent adjuvants, significantly enhancing allergen-specific IgE production in a mouse model.
  • These findings suggest that exposure to particulate matter, such as air pollution, could prime the immune system, leading to heightened allergic reactions to subsequent allergen encounters.