Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cannabinoid receptors and pain.

¹Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK. rgp@aberdeen.ac.uk

Progress in Neurobiology

|February 13, 2001

Summary

Cannabinoids, including endogenous ligands, can reduce acute and tonic pain by interacting with cannabinoid receptors (CB1 and CB2). Research explores their effectiveness and mechanisms in pain modulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.

British journal of pharmacology·2013

Same author

Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation.

British journal of pharmacology·2012

Same author

Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines.

Prostaglandins, leukotrienes, and essential fatty acids·2011

Same author

Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.

British journal of pharmacology·2011

Same author

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂.

Pharmacological reviews·2010

Same author

Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.

British journal of pharmacology·2010

Area of Science:

Neuroscience
Pharmacology
Immunology

Background:

Mammalian tissues express G protein-coupled cannabinoid receptors CB1 and CB2.
CB1 receptors are prominent in neuronal tissues, while CB2 receptors are found in immune cells and some non-neuronal tissues.
The endocannabinoid system, involving endogenous ligands, has been identified, driving research into cannabinoid receptor modulators.

Purpose of the Study:

To review the efficacy of cannabinoids in reducing acute and tonic pain in animal models.
To examine the distribution of cannabinoid receptors within pain pathways.
To discuss the role of these receptors in cannabinoid-mediated antinociception and explore potential alternative mechanisms.

Main Methods:

Review of existing literature on cannabinoid efficacy in animal pain models.
Analysis of cannabinoid receptor distribution in central and peripheral pain pathways.
Discussion of evidence for cannabinoid receptor-mediated antinociception and alternative pathways.

Main Results:

Cannabinoids demonstrate antinociceptive effects in animal models of acute pain.
Cannabinoids can suppress tonic pain induced by nerve damage or inflammation.
The endocannabinoid system plays a role in pain modulation, with potential involvement of non-CB1/CB2 receptors and pathways like vanilloid receptors.

Conclusions:

Cannabinoids are effective in reducing various types of pain through interaction with CB1 and CB2 receptors.
The endocannabinoid system offers therapeutic potential for pain management.
Further research is needed to fully elucidate the complex mechanisms underlying cannabinoid-induced antinociception.

Related Experiment Videos