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Related Experiment Videos

[Fatal vitamin D intoxication].

F Laubenthal, M Reichenberger, D Reinwein

    Deutsche Medizinische Wochenschrift (1946)
    |February 28, 1975
    PubMed
    Summary
    This summary is machine-generated.

    A patient with alopecia maligna experienced a fatal hypercalcaemic crisis after vitamin D3 treatment and sun exposure. This case highlights the risks of vitamin D intoxication and the need for careful patient monitoring.

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    Area of Science:

    • Endocrinology
    • Dermatology
    • Toxicology

    Background:

    • Alopecia maligna is a rare form of hair loss.
    • Vitamin D3 (cholecalciferol) is commonly used for supplementation.
    • Hypercalcaemia is a potential side effect of excessive vitamin D intake.

    Observation:

    • A 43-year-old male with alopecia maligna received 130 mg of vitamin D3 over 4 weeks.
    • Following treatment, the patient experienced intensive sun exposure.
    • Two weeks post-treatment, he developed a hypercalcaemic crisis.

    Findings:

    • The hypercalcaemia was resistant to treatment, even with diuresis.
    • The patient died 5 weeks later from acute cardiac failure.
    • Clinical and histopathological investigations excluded other causes of hypercalcaemia, implicating vitamin D intoxication.

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    Implications:

    • Vitamin D supplementation should be administered cautiously and only when strictly indicated.
    • Regular monitoring of calcium levels is crucial during vitamin D therapy.
    • This case underscores the potential for severe toxicity from vitamin D, particularly when combined with other risk factors like sun exposure.