Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A guide to 17beta-hydroxysteroid dehydrogenases.

J Adamski1, F J Jakob

  • 1GSF-National Research Center for Health and Environment, Institute for Experimental Genetics, Genome Analysis Center, Molecular Endocrinology and Proteomics Group, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

Molecular and Cellular Endocrinology
|February 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Blood and adipose tissue steroid metabolomics and mRNA expression of steroidogenic enzymes in periparturient dairy cows differing in body condition.

Scientific reports·2024
Same author

Solid organ graft-versus-host disease in a recipient of a COVID-19 positive liver graft.

Journal of liver transplantation·2023
Same author

Blood and adipose tissue steroid metabolomics and mRNA expression of steroidogenic enzymes in periparturient dairy cows differing in body condition.

Scientific reports·2022
Same author

Targeted assessment of the metabolome in skeletal muscle and in serum of dairy cows supplemented with conjugated linoleic acid during early lactation.

Journal of dairy science·2021
Same author

Metabolome profiling in skeletal muscle to characterize metabolic alterations in over-conditioned cows during the periparturient period.

Journal of dairy science·2020
Same author

Proteasome activity and expression of mammalian target of rapamycin signaling factors in skeletal muscle of dairy cows supplemented with conjugated linoleic acids during early lactation.

Journal of dairy science·2020

17beta-Hydroxysteroid dehydrogenases (17beta-HSD) regulate steroid hormone activity. This review covers recent 17beta-HSD research and nomenclature updates, highlighting their broad metabolic roles.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Background:

  • 17beta-Hydroxysteroid dehydrogenases (17beta-HSD) are key enzymes in steroid hormone metabolism.
  • These enzymes control the biological activity of hormones through oxidation/reduction at the C17 position.
  • Some 17beta-HSDs also metabolize non-steroidal substrates like alcohols, bile acids, fatty acids, and retinols.

Purpose of the Study:

  • To review recent advancements in 17beta-HSD research.
  • To provide an updated nomenclature for the 17beta-HSD enzyme family.
  • To consolidate current knowledge on the diverse metabolic functions of 17beta-HSDs.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of enzymatic activities and substrate specificities.

Related Experiment Videos

  • Compilation and verification of updated enzyme nomenclature.

    • Main Results:

    • Significant progress has been made in understanding the catalytic mechanisms and physiological roles of various 17beta-HSDs.
    • The diverse substrate profiles of several 17beta-HSDs have been further elucidated.
    • An updated nomenclature reflecting the latest findings has been proposed.

    Conclusions:

    • 17beta-HSDs are crucial regulators of steroid hormone bioactivity and possess broader metabolic functions.
    • Continued research is essential for a comprehensive understanding of 17beta-HSDs' roles in health and disease.
    • The updated nomenclature facilitates clearer communication and future research in the field.