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Technical optimisation of redispersible dry emulsions.
K L Christensen1, G P Pedersen, H G Kristensen
1Department of Pharmaceutics, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Ø, Copenhagen, Denmark.
International Journal of Pharmaceutics
|February 13, 2001
Summary
This study optimized dry emulsions for tablet manufacturing by spray drying and wet granulation. Adding sucrose increased density, and wet granulation with ethanol preserved reconstitution properties for high-lipid tablets.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Dry emulsions are challenging to formulate for direct tablet processing.
- Hydroxypropylmethylcellulose (HPMC) and fractionated coconut oil were used as carrier/emulsifier and lipid phase, respectively.
Purpose of the Study:
- To develop spray-dried dry emulsions suitable for tablet processing.
- To investigate excipients for enhancing dry emulsion density.
- To optimize the formulation for improved flowability, compressibility, and reconstitution.
Main Methods:
- Spray drying of liquid oil-in-water emulsions using HPMC.
- Evaluation of excipients, including sucrose, to increase emulsion density.
- Wet granulation with ethanol to improve flow and compaction properties.
Main Results:
- Sucrose addition yielded redispersible dry emulsions with increased density.
- Wet granulation with ethanol produced free-flowing, compactable dry emulsions while preserving reconstitution.
- Tablets with up to 20% lipid content exhibited suitable properties.
Conclusions:
- Dry emulsions can be successfully optimized for tablet processing via wet granulation.
- The developed method allows for the production of stable, high-density dry emulsions suitable for pharmaceutical formulations.