Simulation of skin permeability in chitosan membranes

To provide an alternative means of evaluating transdermal drug delivery systems, membranes of chitosan were developed. The membranes were prepared by cast-drying method. The effects of chitosan concentration, sodium tripolyphosphate (NaTPP) concentration and crosslinking (CL) time on flux and lag time were studied using central composite design. It was observed that chitosan membrane at a particular composition simulated the permeation of diclofenac sodium through rat skin The mathematical model developed in the present study can be used to simulate the permeation of drugs through different species of animal skins.