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Multicentric reference values for some quantities measured with the Elecsys 2010 analyser.
X Fuentes-Arderiu1, M Ferrer-Masferrer, J M González-Alba
1Servei de Bioquímica Clínica, Ciutat Sanitària i Universitària de Bellvitge, L'Hopitalet de Llobregat, Catalonia, Spain. xfa@csub.scs.es
Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 13, 2001
Summary
Clinical labs in Spain collaborated to establish reference values for thyrotropin, thyroid hormones, cobalamins, and folates. This multicentric approach, using the Elecsys 2010 analyser, provides a model for industry-laboratory partnerships in diagnostics.
Area of Science:
- Clinical Chemistry
- Laboratory Medicine
- In Vitro Diagnostics
Background:
- Establishing reliable reference values is crucial for accurate clinical laboratory testing.
- Previous efforts lacked standardized multicentric approaches for key analytes.
Purpose of the Study:
- To develop multicentric reference limits for thyrotropin, non-protein bound thyroxine, triiodothyronine, cobalamines, and folates.
- To evaluate a collaborative model between clinical laboratories and diagnostic industry suppliers.
Main Methods:
- A multicentric study involving several Spanish clinical laboratories.
- Utilized the Elecsys 2010 analyser for all measurements.
- Reference limits were estimated based on pooled data, adhering to International Federation of Clinical Chemistry guidelines.
Main Results:
- Successfully generated multicentric reference limits for the specified analytes.
- Demonstrated the feasibility of a collaborative virtual laboratory approach.
- The pooled reference values represent a blend from individual laboratory findings.
Conclusions:
- The study established a successful model for inter-laboratory cooperation in producing diagnostic reference values.
- This collaborative effort, supported by industry, enhances the reliability of clinical laboratory results.
- The findings provide a valuable framework for future multicentric reference value studies.