Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosomal abnormalities in pituitary adenomas.

M J Bello1, J M de Campos, M E Kusak

  • 1Laboratorio de Oncogenética Molecular, Unidad de Investigación, Departamento de Cirugía Experimental, Hospital Universitario La Paz, Paseo Castellana 261, 28046, Madrid, Spain.

Cancer Genetics and Cytogenetics
|February 13, 2001
PubMed
Summary

Cytogenetic analysis of 30 pituitary adenomas revealed chromosomal abnormalities in over half of the tumors. Specific recurrent numerical deviations were identified, suggesting potential genetic drivers in pituitary tumor development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Minimizing risk: evaluation of the relationship between femoral stem loosening and the risk of presenting with peri-prosthetic hip fracture].

Acta ortopedica mexicana·2024
Same author

Vaginal neutrophil infiltration is contingent on ovarian cycle phase and independent of pathogen infection.

Frontiers in immunology·2022
Same author

[Pro-inflammatory cytokines in the knee fat pad and subcutaneous fat of the thigh in osteoarthritic patients].

Acta ortopedica mexicana·2020
Same author

Impact of Physiological Signals Acquisition in the Emotional Support Provided in Learning Scenarios.

Sensors (Basel, Switzerland)·2019
Same author

[Intra-articular migration of a tibial bone block after an anterior cruciate ligament reconstruction using a bone-tendon-bone graft].

Acta ortopedica mexicana·2018
Same author

Intrathecal administration of autologous bone marrow stromal cells improves neuropathic pain in patients with spinal cord injury.

Neuroscience letters·2018

Area of Science:

  • Endocrinology
  • Genetics
  • Oncology

Background:

  • Pituitary adenomas are common tumors arising from the pituitary gland.
  • Understanding the genetic basis of pituitary adenomas is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the cytogenetic landscape of pituitary adenomas.
  • To identify recurrent chromosomal abnormalities in these tumors.

Main Methods:

  • Cytogenetic analysis was performed on 30 pituitary adenomas.
  • Direct and short-term in vitro culture methods were employed.

Main Results:

  • 14 out of 30 tumors exhibited a normal chromosome complement.
  • 5 adenomas showed hyperdiploid or near-triploid modal chromosome numbers.

Related Experiment Videos

  • 12 samples displayed recurrent numerical deviations, including gains of chromosomes 4, 7, 8, 9, 12, and 20, and losses of chromosomes 10, 14, 19, and 22.
  • 4 adenomas had structural chromosome rearrangements without a clear recurrent pattern.

    • Conclusions:

    • Over half of the studied pituitary adenomas harbor cytogenetic abnormalities.
    • Specific recurrent numerical chromosomal changes were identified, potentially contributing to tumorigenesis.
    • Further research is warranted to explore the functional impact of these genetic alterations.