Related Experiment Video
Updated: Jul 15, 2026

Infant Auditory Processing and Event-related Brain Oscillations
Published on: July 1, 2015
Age-related changes in olfactory processing detected with olfactory event-related brain potentials using
Abstract:
Previous olfactory event-related potential (OERP) studies often employed the Velopharyngeal Closure (VC) method, which prevents respiratory air flow in the nose during odor presentation. However, the use of VC has limited the application of OERPs to populations able to perform this artificial breathing technique. The present study investigated the effects of Natural Breathing (NB) in comparison to VC on OERP latency and amplitude in young (mean age: 24 years) and elderly (mean age: 71 years) adults. OERPs were recorded from three midline scalp electrodes (Fz, Cz, Pz) for 15 trials in each breathing condition with an interstimulus interval of 3.5 min, using amyl-acetate as stimulus. Subjects were asked to report perceived stimulus intensity. A thermistor placed inside one nostril monitored nasal respiration and performance of VC. In the NB condition, subjects were instructed to breathe normally through mouth and nose, while stimulus presentation occurred during inspiration. In both breathing conditions, elderly subjects showed significantly smaller N1-P2 and N1-P3 interpeak amplitudes and longer latencies for N1, P2, P3 than younger subjects. VC generated significantly larger N1-P2 amplitudes across all electrode sites, whereas Natural Breathing produced a trend towards shorter P3 latencies. No significant interaction was found between age and breathing technique. The present investigation showed that the OERP is a sensitive measure for detecting age-related changes in olfactory function regardless of breathing technique.
More Related Videos
Related Concept Videos
Olfaction
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure
Physiology of Smell and Olfactory Pathway
The olfactory...
Neural Control of Respiration
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
Prosopagnosia

