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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Altered atypical coupling of gamma-aminobutyrate type A receptor agonist and convulsant binding sites in

S T Sinkkonen1, R M Mihalek, G E Homanics

  • 1Department of Pharmacology and Clinical Pharmacology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.

Brain Research. Molecular Brain Research
|February 13, 2001
PubMed

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...