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Polyphyletic evolution of type II restriction enzymes revisited: two independent sources of second-hand folds
J M Bujnicki1, M Radlinska, L Rychlewski
1Bioinformatics Laboratory, International Institute of Molecular and Cell Biology, ul. ks. Trojdena 4, 02-109, Warsaw, Poland. iamb@bioinfo.pl
Trends in Biochemical Sciences
|February 13, 2001
Abstract:
Using algorithms for protein sequence analysis we predict that some of the canonical type II and type IIS restriction enzymes have an active site with a substantially different architecture and fold from the "typical" PD-(D/E)xK superfamily. These results suggest that they are related to nucleases from the HNH and GIY-YIG superfamilies.