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Association between funisitis and elevated interleukin-6 in cord blood
N Naccasha1, R Hinson, A Montag
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA.
Obstetrics and Gynecology
|February 13, 2001
Summary
Elevated interleukin-6 (IL-6) in umbilical cord blood is linked to funisitis in preterm neonates. This finding suggests IL-6 can effectively screen for funisitis, aiding early treatment for fetal inflammatory syndrome.
Area of Science:
- Neonatal immunology
- Perinatal pathology
- Biomarker discovery
Background:
- Funisitis, an umbilical cord inflammation, poses risks to preterm neonates.
- Identifying funisitis early is crucial for timely intervention.
- Interleukin-6 (IL-6) is a key inflammatory marker.
Purpose of the Study:
- To investigate the association between elevated umbilical venous cord blood IL-6 and funisitis.
- To evaluate IL-6 as a potential screening tool for funisitis in preterm neonates.
Main Methods:
- Umbilical venous cord blood samples were collected from 92 neonates at delivery.
- Plasma IL-6 concentrations were measured using immunoassay.
- Placental and umbilical cord histology confirmed funisitis and chorioamnionitis.
Main Results:
- A significant association was found between funisitis and elevated plasma IL-6 (≥10 pg/mL).
- 93% of neonates with funisitis had elevated IL-6 levels.
- The negative predictive value of IL-6 for funisitis was 98%.
Conclusions:
- IL-6 immunoassay is a valid screening method for funisitis in preterm neonates.
- Elevated cord blood IL-6 may help identify neonates needing early treatment for systemic fetal inflammatory syndrome.