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Bone mineral metabolism after total gastrectomy
J T Heiskanen1, H Kröger, M Pääkkönen
1Department of Surgery, North-Carelian Central Hospital, Joensuu, Finland. jorma.heiskanen@pkshp.fi
Bone
|February 13, 2001
Summary
Total gastrectomy significantly reduces bone mineral density (BMD) in patients, increasing fracture risk. Biochemical tests were poor indicators of bone loss after this gastric surgery.
Area of Science:
- Orthopedics
- Endocrinology
- Gastroenterology
Background:
- Gastric surgery, particularly total gastrectomy, is primarily performed for gastric malignancy.
- The long-term effects of total gastrectomy on bone health remain a significant clinical concern.
Purpose of the Study:
- To investigate the impact of total gastrectomy on bone mineral density (BMD) and bone metabolism.
- To compare BMD in post-gastrectomy patients with age- and gender-matched healthy controls.
Main Methods:
- Evaluated 18 patients who underwent total gastrectomy (mean interval: 71 months post-operation).
- Measured BMD using dual-energy X-ray absorptiometry (DXA).
- Compared patient BMD with 46 healthy controls, analyzing T and Z scores.
Main Results:
- Significantly lower BMD was observed in post-gastrectomy patients compared to controls across multiple skeletal sites (lumbar spine, femoral neck, Ward's triangle, greater trochanter) in both genders (p < 0.05).
- Z scores indicated reduced bone mass in these patients.
- Biochemical measurements showed poor correlation with BMD and limited diagnostic value for osteopenia.
Conclusions:
- Total gastrectomy has a detrimental effect on bone mineral status.
- Patients who have undergone total gastrectomy are at an increased risk of fractures.