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Inappropriate left ventricular mass in normotensive and hypertensive patients
A Celentano1, V Palmieri, N D Esposito
1Inter-University Center for Study and Research on Obesity, Department of Clinical and Experimental Medicine, Federico II University Hospital, School of Medicine, Naples, Italy.
Insights
Inappropriate left ventricular (LV) mass, exceeding predicted levels, is linked to overweight and reduced heart muscle function in both normal and high blood pressure adults.
Area of Science:
- Cardiovascular Medicine
- Cardiac Physiology
- Echocardiography
Background:
- Left ventricular (LV) mass is a key indicator of cardiac health.
- Abnormal LV mass can signify underlying cardiovascular issues.
- Predictive models help assess normal LV mass based on physiological factors.
Purpose of the Study:
- To investigate the cardiovascular characteristics of individuals with "inappropriate" left ventricular mass.
- To determine if "inappropriate" LV mass is associated with specific clinical and functional parameters.
- To compare findings in both normotensive and hypertensive populations.
Main Methods:
- Evaluation of cardiovascular features in adults.
- Identification of subjects with left ventricular mass exceeding predicted values for stroke work, gender, and height.
- Analysis of associations between "inappropriate" LV mass and factors like body weight, LV geometry, and myocardial function.
Main Results:
- "Inappropriate" left ventricular mass was observed in both normotensive and hypertensive adults.
- This condition was associated with being overweight.
- Concentric left ventricular geometry and reduced myocardial systolic function were prevalent in subjects with "inappropriate" LV mass.
Conclusions:
- "Inappropriate" left ventricular mass is a significant finding beyond hypertension.
- Overweight, altered LV geometry, and impaired systolic function are linked to "inappropriate" LV mass.
- These findings highlight the importance of assessing LV mass independently of blood pressure status.
Abstract:
We evaluated cardiovascular features of normotensive and hypertensive adults with left ventricular (LV) mass values exceeding levels predicted for given stroke work, gender, and height, termed "inappropriate" LV mass. Inappropriate LV mass is associated with overweight, concentric LV geometry, and low myocardial systolic function not only in hypertensive subjects, but also in normotensive subjects.