Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genomics: implications for toxicology.

K Olden1, J Guthrie

  • 1Department of Health and Human Services, National Institute of Environmental Health Sciences and National Toxicology Program, National Institutes of Health, Research Triangle Park, NC 27709, USA. olden@niehs.nih.gov

Mutation Research
|February 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multicentre, clinical evaluation of a hydro-responsive wound dressing: the Glasgow experience.

Journal of wound care·2017
Same author

Social capital strategies to enhance hepatitis C treatment awareness and uptake among men in prison.

Journal of viral hepatitis·2016
Same author

Clinical acceptability of a dressing with matrix technology: a multisite evaluation of acute and chronic wounds.

Journal of wound care·2016
Same author

Inhibition of transforming growth factor-β-activated kinase-1 blocks cancer cell adhesion, invasion, and metastasis.

British journal of cancer·2012
Same author

PI3K/Akt signalling is required for the attachment and spreading, and growth in vivo of metastatic scirrhous gastric carcinoma.

British journal of cancer·2012
Same author

Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1.

British journal of cancer·2011
Same journal

Monoallelic germline RAD51C, RAD51D, and BRIP1 variants in hereditary cancer testing: Variant spectrum and clinical counselling implications.

Mutation research·2026
Same journal

Prediction of hepatocellular carcinoma associated biomarkers in TP53 gene; A comprehensive in silico analysis.

Mutation research·2026
Same journal

IDH1 mutation promotes angiogenesis via upregulation of hypoxia inducible factor 1 alpha in glial tumors.

Mutation research·2026
Same journal

Targeting overexpressed oncogenes in esophageal cancer through miRNA-mediated gene silencing: Insights from binding affinity and thermodynamic profiling.

Mutation research·2026
Same journal

The active compound quercetin from Polygonum cuspidatum targets COL3A1 to enhance CD8⁺ T cell cytotoxicity in gastric cancer.

Mutation research·2026
Same journal

E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.

Mutation research·2026
See all related articles

The Environmental Genome Project (EGP) aims to find human genetic variations linked to environmental exposures. This research will help understand disease susceptibility and advance public health and medicine.

Area of Science:

  • Genetics
  • Environmental Health
  • Human Disease Susceptibility

Background:

  • Genetic factors significantly influence population disease variation, but identifying specific genes remains challenging.
  • Current understanding of human diseases largely stems from studies of rare monogenic disorders.
  • The Environmental Genome Project (EGP) addresses the need to link genetic variations to environmental factors.

Purpose of the Study:

  • To identify human polymorphisms associated with susceptibility to specific environmental agents.
  • To develop a comprehensive database of genetic variations within diverse US populations.
  • To lay the groundwork for understanding the functional significance of genetic variations.

Main Methods:

  • Resequencing DNA samples from diverse US racial and ethnic groups to create a variation database.

Related Experiment Videos

  • Utilizing gene-expression profiling to detect polymorphisms in specific genes.
  • Developing sophisticated proteomics, population-based, and animal model studies to determine functional significance.

    • Main Results:

    • Established a strategy for identifying human polymorphisms linked to environmental exposures.
    • Initiated the development of a database of genetic variations across representative US populations.
    • Highlighted the challenges and future directions for functional analysis of identified polymorphisms.

    Conclusions:

    • The EGP's approach will significantly advance the understanding of genetic susceptibility to environmental agents.
    • Identifying and understanding the functional significance of polymorphisms will revolutionize public health and clinical medicine.
    • This research is crucial for transforming pharmaceutical development and personalized medicine.